Orlistat is used with an individualized low-calorie, low-fat diet and exercise program to help people lose weight . Prescription orlistat is used in overweight people to promote weightloss. Orlistat is also used after weight-loss as a remedy to help people keep from gaining back the weight.

Orlistat belongs in the class of medications called lipase inhibitors. It works in the intestines by blocking absorption of some of the fat in foods eaten. This unabsorbed fat is then removed by the organism.

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